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Adult Mouse Venous Hypertension Model: Common Carotid Artery to External Jugular Vein Anastomosis.
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遗传性出血性telangiectasia的小鼠模型具有一般化的血管异常

Evelyn Torsney1, Richard Charlton, Austin G Diamond

  • 1Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, NE1 3BZ, UK.

Circulation
|April 2, 2003
PubMed
概括

遗传性出血端膜切除症 (HHT) 涉及血管异常. 这项研究发现,内分泌素基因突变导致脆弱的血管缺乏光滑肌肉细胞,导致HHT的变异性出血.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...