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在使用FastHARP的心磁共振应力测试期间检测定量性缺血

Dara L Kraitchman¹, Smita Sampath, Ernesto Castillo

¹Johns Hopkins University, School of Medicine, Department of Radiology, MD 21287-0845, USA. dara@mri.jhu.edu

|April 2, 2003

概括

快速波相 (FastHARP) MRI提供了一种更快,独立于操作者的方法,用于在心脏应力测试期间检测缺血. 这种技术比传统的电影MRI和心电图更早地发现缺血,提高了患者的安全性.

科学领域:

心血管成像 - 心血管成像
医学物理医学物理

背景情况:

电脑心电图在高场MRI期间检测缺血是不可靠的.
墙壁运动异常需要专家观察员在MR应力测试期间检测.
急性冠状动脉封闭需要可靠,客观的缺血检测方法.

研究的目的:

调查快速波相 (FastHARP) 核磁共振成像 (MRI) 用于定量,经营者独立的缺血检测.
在临床前模型中评估FastHARPMRI在急性冠状动脉封闭期间的疗效.
将FastHARPMRI检测时间与传统的电影MRI和心电图进行比较.

主要方法:

在混血犬中引起了急性冠状动脉封闭.
连续的FastHARPMRI图像被获取以确定区域墙壁应变.
传统的电影壁画动画图像是在随后的缺血发作期间获得的.

主要成果:

快速HARPMRI检测出缺血明显早于电影MRI (9.5±5比33±14秒).
通过FastHARPMRI检测出缺血,而在心电图变化之前平均需要54秒.
该方法在识别急性冠状动脉封闭期间缺血发病的过程中被证明有效.

结论:

快速波相 (FastHARP) MRI 显示了客观缺血病诊断的潜力.
这种技术在MR应力测试期间有望识别显著的冠状动脉病变.
在心脏成像中,FastHARP MRI提供了一种快速,非主观的方法来提高患者的安全性.

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