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血 natriuretic水平的增加反映了主动脉狭窄症的症状发作
Ivor L Gerber1, Ralph A H Stewart, Malcolm E Legget
1Cardiology Department, Green Lane Hospital, Auckland, New Zealand.
Circulation
|April 2, 2003
概括
增加的尿素含量,包括N端前脑尿素 (NT-proBNP),表明有症状的大动脉狭窄. 这些测量可以帮助评估疾病的严重程度,并指导大动脉狭窄患者的治疗决策.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 膜心脏疾病 膜心脏疾病
背景情况:
- 症状发作在主动脉狭窄 (AS) 自然史中至关重要,并决定了门更换.
- 这项研究调查了尿素水平,AS严重程度和心脏症状之间的联系.
研究的目的:
- 评估大动脉狭窄症中尿酸水平与疾病严重程度之间的关联.
- 为了确定 natriuretic水平是否与AS患者的心脏症状相关.
主要方法:
- 74名AS患者和100名对照人接受了症状评估,心声学和血性尿素测量 (心房,BNP,N-BNP).
- 进行了统计分析,以比较症状和无症状患者之间的水平,以及纽约心脏协会 (NYHA) 课程.
主要成果:
- 与无症状患者 (0.99厘米) 相比,有症状的AS患者的大动脉面积较小 (0.71厘米2).
- 血N-BNP水平在有症状的患者 (中位数为112 pmol/L) 比无症状患者 (33 pmol/L) 显著更高.
- 在有症状的AS患者中,调整后的N-BNP水平是1.74倍高;在NYHA类 (P<0.0001) 中,水平增加.
结论:
- 血 natriuretic 的水平在有症状的患者上升,有大动脉狭窄.
- 纳类的测量可以补充临床和心声学评估在管理AS.
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