淋巴细胞上的LIR-1表达,以及肺移植受体中的细胞巨型病毒疾病
Louise Berg1, Gerdt C Riise, David Cosman
1Microbiology and Tumourbiology Centre, Karolinska Institutet, Stockholm, Sweden.
Lancet (London, England)
|April 4, 2003
概括
在淋巴细胞上测量白细胞免疫球蛋白样受体-1 (LIR-1) 表达可能有助于预测肺移植患者的人类细胞巨化病毒疾病. 增加LIR-1表达可以在病毒DNA检测到之前表明早期感染.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 移植医学 移植医学 移植医学
背景情况:
- 人类细胞巨乳病毒 (CMV) 感染是肺移植接受者疾病的重要原因.
- 白细胞免疫球蛋白类受体-1 (LIR-1) 是一种抑制受体,它与CMV编码的MHC I类同类物体UL18.18结合.
研究的目的:
- 调查CMV再激活是否影响外围血液淋巴细胞LIR-1表达.
- 确定LIR-1表达是否可以作为CMV疾病肺移植后的早期标志物.
主要方法:
- 在13名肺移植患者中,分析了周围血液淋巴细胞的LIR-1表达.
- 人类CMV病毒载量使用PCR量化.
- LIR-1表达水平与CMV疾病的发展相关.
主要成果:
- 在患有CMV疾病的患者中观察到LIR-1表达细胞的显著增加.
- 这种LIR-1表达的升高在PCR检测病毒DNA之前几周.
- 在13名患者中,有8人患上了CMV疾病.
结论:
- 周围血液淋巴细胞上的LIR-1表达在肺移植患者的人类CMV活性化过程中发生变化.
- 监测LIR-1表达可能为CMV疾病提供一种新的早期诊断方法,使得及时干预成为可能.
- 这一发现对改善固体器官移植患者的治疗结果有意义.
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