在健康的年轻男性中,传染病原体和内皮功能之间没有关联
Paul Khairy1, Stephane Rinfret, Jean-Claude Tardif
1Department of Medicine, Montreal Heart Institute, University of Montreal, Quebec, Canada.
Circulation
|April 19, 2003
概括
这项研究发现,常见的感染,如克拉米迪亚肺炎 (CP) 和年轻男性内皮功能障碍之间没有联系. 这些感染似乎不是冠状动脉疾病的早期触发因素.
科学领域:
- 心血管研究研究心血管研究
- 传染病流行病学 传染病流行病学
- 血管生物学 血管生物学
背景情况:
- 冠状动脉疾病 (CAD) 与感染有关,但其前体内皮功能障碍的作用尚不清楚.
- 这项研究研究了常见感染和内皮功能之间的关联.
研究的目的:
- 评估是否感染克拉米迪亚肺炎 (CP),细胞巨化病毒 (CMV),爱斯坦-巴尔病毒 (EBV) 或海利cobacter pylori (HP) 与年轻健康男性内皮功能下降有关.
主要方法:
- 一项对65名男性受试者 (年龄在20-45岁) 进行的横截面研究,没有CAD风险因素.
- 通过流量介导的手臂血管扩张来测量内皮功能.
- 对抗CP,抗CMV,抗EBV,抗HP抗体和C反应蛋白的血清检测.
主要成果:
- 观察到EBV (88.9%) 和CP (65.1%) 的高血清流行率.
- 没有发现内皮功能与对单个药物,感染负担或C-反应蛋白的血清阳性之间有显著的关联.
- 回归分析,控制年龄,血压和脂质,没有显示任何联系.
结论:
- 慢性感染CP,CMV,EBV或HP与内皮功能障碍没有关联.
- 这些发现表明,这些病原体不是冠状动脉疾病的早期触发因素.
- 进一步的研究可能会探索它们在动脉样硬化晚期的作用.
更多相关视频
08:43Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
Published on: February 14, 2017
07:56Monitoring Changes in Human Umbilical Vein Endothelial Cells upon Viral Infection Using Impedance-Based Real-Time Cell Analysis
Published on: May 5, 2023
相关概念视频
01:26Factors Affecting the Risk of Infection
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
01:25Endocarditis I: Introduction
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...