相关实验视频
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Brain Imaging Investigation of the Neural Correlates of Emotion Regulation
Published on: August 26, 2011
心房动和不规则的心室反应对人类受试者的交感神经活动的影响
Stephen L Wasmund1, Jian-Ming Li, Richard L Page
1University of Texas Southwestern Medical Center and Dallas Veterans Affairs Medical Center, Dallas, TX 75390-9047, USA.
Circulation
|April 19, 2003
概括
心房动 (AF) 显著增加了交感神经活动 (SNA),部分原因是心跳不规律. 恢复正常的鼻节律 (NSR) 可能有利于心力衰竭患者.
科学领域:
- 心脏病学 心脏病学
- 神经科学是一个神经科学.
- 电子生理学 电子生理学
背景情况:
- 已知心房动 (AF) 的血液动力学变化,但神经变化尚不清楚.
- 假设AF增加了交感神经活动 (SNA),心室反应不规则有助于交感兴奋.
研究的目的:
- 研究诱导性心房 (AF) 对交感神经活动 (SNA) 的影响.
- 确定AF期间心室不规则反应是否有助于增加SNA.
主要方法:
- 在正常鼻腔节律 (NSR) 和诱导的AF期间,记录了8名患者的SNA,血压 (BP),中央静脉压 (CVP) 和心率.
- 在转换为NSR的患者中,执行右心房 (RA) 节奏模拟不规则和规则的心室反应.
主要成果:
- 与NSR相比,SNA在诱导AF期间显著增加 (171%与100%相比,P<0.01).
- 不规则的RA节奏 (RA-不规则) 导致SNA高于常规节奏 (124%对比91%,P=0.03).
- 诱导的AF显示了BP下降和CVP增加的趋势.
结论:
- 诱导的AF显著提高SNA,部分原因是心室反应不规则.
- 恢复NSR或节律规律可能会带来好处,特别是对于心力衰竭患者.
关键词:
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