在健康的男性中,C-反应蛋白和血栓栓塞性中风的未来风险
J David Curb1, Robert D Abbott, Beatriz L Rodriguez
1Pacific Health Research Institute, Honolulu, Hawaii 96813, USA. curb@phri.hawaii-health.com
Circulation
|April 19, 2003
概括
中年男性的C-反应蛋白 (CRP) 水平升高,特别是那些没有传统风险因素的男性,与20年内血栓栓塞性中风 (TE) 的风险增加有关. 这表明CRP可能成为心血管疾病的有价值的查工具.
科学领域:
- 生物医学研究的研究.
- 心血管流行病学心血管流行病学
- 炎症标志物的炎症标志物
背景情况:
- C-反应蛋白 (CRP) 与血栓栓塞性 (TE) 中风有关.
- 其他风险因素对这种关联的影响尚未完全理解.
研究的目的:
- 进一步调查CRP水平与TE中风风险之间的关系.
- 检查其他心血管风险因素如何改变CRP-中风相关性.
主要方法:
- 一项长达20年的随访研究,涉及259例TE中风病例和1348例对照.
- 在CRP测量时,参与者年龄在48-70岁之间.
主要成果:
- 20年来,CRP水平与TE中风风险有积极的关联.
- 在最高CRP四分位数中,中风风险随着时间的推移显著增加,在10-15年内达到3.8倍.
- 在年轻男性,非吸烟者以及没有高血压或糖尿病的人群中观察到更强烈的关联.
结论:
- 中年成人时CRP升高可能表明TE中风风险增加,特别是在传统风险因素较少的男性中.
- 可以考虑进行CRP查,以确定患心血管疾病风险较高的健康男性.
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