在老年人中,β2-上腺素受体多态性和发生心血管事件的风险
Susan R Heckbert1, Lucia A Hindorff, Karen L Edwards
1Department of Epidemiology, University of Washington, Seattle, USA. heckbert@u.washington.edu
Circulation
|April 19, 2003
概括
在老年人中,β2-上腺体受体基因的Glu27变体可能会降低冠状动脉事件风险. 这一发现与对心血管健康和同情反应的遗传影响有关.
科学领域:
- 药物基因组学 药物基因组学
- 心血管医学 心血管医学
- 人类遗传学 人类遗传学
背景情况:
- 代码子16和27的β2-上腺素受体 (ADRB2) 的遗传变异影响了交感神经系统的反应.
- 这些多态性因其对心血管疾病风险的潜在作用而受到研究.
研究的目的:
- 研究ADRB2基因多态 (Arg16Gly和Gln27Glu) 与心血管事件风险之间的关联.
- 在心血管健康研究的背景下分析这些遗传关联.
主要方法:
- 在808名黑人和4441名白人参与者 (平均年龄73岁) 的队列中,ADRB2多态 (Arg16Gly,Gln27Glu) 的基因定型.
- 未来7至10年的随访以确定发生的冠状动脉事件,缺血性中风和结合性心血管事件.
- 统计分析使用危险比率和置信区间来评估基因型-事件关联,按种族分层.
主要成果:
- 对ADRB2多态的等位基频率因种族而异,但不因年龄或高血压状况而异.
- 与Gln27同胞相比,Glu27等位基的携带者表现出冠状动脉事件的风险降低 (HR,0.82;95% CI,0.700.95).
- 在Gly16携带者与Arg16同胞体 (HR,0.88;95%CI,0.721.07) 之间观察到一种降低冠状动脉事件风险的趋势,尽管在统计学上不显著.
结论:
- 在老年人群中,β2-上腺体受体的Glu27异位基因与发生冠状动脉事件的风险较低有关.
- 这些发现表明,特定的ADRB2基因型在调节老年人心血管风险方面可能发挥作用.
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