过酶增殖器激活的受体三角体激活脂肪代谢,以预防肥胖
Yong-Xu Wang1, Chih-Hao Lee, Sambath Tiep
1Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Cell
|April 23, 2003
概括
过氧体增殖器激活受体三角 (PPARdelta) 激活增强脂肪酸氧化和能量消耗,导致对肥胖的抵抗. 这表明PPARdelta是治疗代谢障碍的关键目标.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 肥胖研究的研究.
- 脂质代谢 脂质的代谢
背景情况:
- 在脂质代谢中PPARgamma和PPARalpha的作用已经得到了很好的证实.
- 在脂质代谢中PPARdelta的功能仍然在很大程度上是未知的.
研究的目的:
- 调查PPARdelta在脂肪组织中对脂质代谢和肥胖的作用.
- 为了确定PPARdelta激活是否可以预防或逆转肥胖.
主要方法:
- 在小鼠的脂肪组织中向激活PPARdelta.
- 向饮食诱导和遗传肥胖的小鼠 (Lepr) 给予PPARdelta激动剂.
- 对吃高脂肪饮食的PPAR-delta缺乏的小鼠进行分析.
- 使用脂肪细胞和骨肌细胞进行体外研究.
主要成果:
- 在脂肪组织中PPARdelta激活诱导脂肪酸氧化和能量消散的基因.
- 具有激活PPARdelta的小鼠对饮食诱导和遗传肥胖症具有抵抗力.
- 在肥胖小鼠中,PPARdelta激动剂治疗减少了脂质积累.
- 缺少PPAR-delta的小鼠显示能量脱和肥胖性降低.
- 在体外,PPARdelta的激活促进了脂肪细胞和肌肉细胞中的脂肪酸氧化.
结论:
- PPARdelta是燃烧脂肪的重要调节者.
- PPARdelta激活可以改善脂质样本,减少脂肪.
- PPARdelta代表了肥胖和相关疾病的潜在治疗标.
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