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对于严重的慢性缺血性心力衰竭,进行跨内心,自主骨髓细胞移植
Emerson C Perin1, Hans F R Dohmann, Radovan Borojevic
1Texas Heart Institute at St Luke's Episcopal Hospital, Houston, Tex, USA. eperin@crescentb.net
Circulation
|April 23, 2003
概括
骨髓干细胞注射对于严重心力衰竭患者是安全的. 这种治疗改善了心脏功能和血液流动,为缺血性心脏病提供了潜在的新疗法.
科学领域:
- 心血管医学 心血管医学
- 再生医学是一种再生医学.
- 干细胞疗法是一种干细胞疗法.
背景情况:
- 末期缺血性心脏病在治疗中带来了重大挑战.
- 新血管化,改善 perfusion 和心肌收缩性对于管理心力衰竭至关重要.
研究的目的:
- 评估自主单核骨髓细胞的跨内脏注射的安全性和有效性.
- 评估在患有严重缺血性心脏病的患者中促进新血管化和改善心脏功能的潜力.
主要方法:
- 这是一项前性,非随机的开放性研究,涉及21名患者 (14名治疗,7名对照).
- 骨髓单核细胞被注射到通过电机绘图 (NOGA导管) 识别的可活性心肌中.
- 评估包括临床评估,运动压力测试,心声学,SPECT输液扫描和霍尔特监测.
主要成果:
- 在基线人口统计或运动变量之间没有显著差异.
- 2个月后,SPECT分析显示可逆性缺陷减少,左心室功能总体改善 (P=0.02).
- 在4个月后,接受治疗的患者表现出改善的射出分数 (20%至29%,P=0.003) 和降低的末缩体积 (P=0.03),注射部分有显著的机械改善 (P<0.0005).
结论:
- 骨髓衍生干细胞的心内注射在患有严重心力衰竭的人群中相对安全.
- 该程序显示了改善心肌动脉血流和增强区域和全球左心室功能的潜力.
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