大脑天然尿素作为肺栓塞患者不良结果的预测因子
M ten Wolde1, I I Tulevski, J W M Mulder
1Department of Vascular Medicine, F4-138, Academic Medical Center, Meibergdreef 9, PO Box 22660, 1100 DD Amsterdam, The Netherlands. m.tenwolde@amc.uva.nl
Circulation
|April 23, 2003
概括
血大脑尿性 (BNP) 水平可以预测肺栓塞患者的致命结果. 较高的BNP (>21.7 pmol/L) 表示死亡风险为17%,而较低的水平则表明99%的无事故结局机会.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 生物标志物研究 生物标志物研究
背景情况:
- 肺栓塞 (PE) 携带显著的死亡风险 (2-7%),尽管抗凝剂治疗.
- 确定PE的预后标志物对于风险分层和患者管理至关重要.
研究的目的:
- 调查血脑内尿素 (BNP) 作为诊断为急性肺栓塞的患者致命结局的预测因子.
- 评估PE患者的基线BNP水平和临床结果之间的关系.
主要方法:
- 一项涉及110名连续肺栓塞患者的研究.
- 在呈现时测量血BNP水平.
- 分析BNP度三角形,以确定与结果事件的关联.
- 计算NBP水平的正负预测值.
主要成果:
- 血BNP水平>21.7 pmol/L与17%的肺栓塞死亡风险相关 (95% CI,6%至33%).
- 一个BNP值<21.7 pmol/L表明一个高负预测值 (99%;95% CI,93%到100%) 无事件的结果.
结论:
- 血BNP水平是急性肺栓塞患者不良后果的重要预测指标.
- 这项研究提供了第一个证据,将血BNP水平与急性PE的预后联系起来.
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