在血管性正常冠状动脉的血管封闭期间是否存在功能性附带流动?
Kerstin Wustmann1, Stephan Zbinden, Stephan Windecker
1Department of Cardiology, Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.
Circulation
|April 23, 2003
概括
功能性冠状动脉附带流存在于正常冠状动脉的个体中. 在这些患者中,很大一部分在短暂的闭塞期间没有表现出心肌缺血的迹象,这表明有保护性的自然绕道.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 身体生理学 身体生理学
背景情况:
- 在血管学上正常的冠状动脉患者中,冠状动脉附带流的存在和功能意义在很大程度上是未知的.
- 以前存在的冠状动脉附带血管可以作为自然绕道,在冠状动脉疾病的背景下提供保护.
研究的目的:
- 通过在冠状动脉中预先存在的静脉瘤,而没有显著的狭窄,来调查附带流的存在和功能能力.
- 确定这些附带物质是否在暂时冠状动脉封闭期间提供对心肌缺血的保护.
主要方法:
- 附带流量指数 (CFI) 用传感器尖端导线测量了100名患者在冠状动脉的1分钟气球阻塞期间.
- 同时测量了平均大动脉压力,中央静脉压力和冠状动脉压力.
- 根据其他冠状动脉中缺少或部分存在狭窄性病变的情况来对患者进行分类.
主要成果:
- 所有患者的平均CFI为0.18±0.08,范围为0.04到0.36.
- 22名个人 (22%) 显示CFI≥0.25,表明已开发良好的抵押品.
- 在气球封闭期间,17名患者在冠心电图上没有心肌缺血症状,26名患者报告没有心痛.
结论:
- 功能性冠状动脉附带血管存在于具有血管学上正常冠状动脉的人身上.
- 在这些人中,很大一部分 (20-25%) 具有足够的附带循环,可以在短暂的闭塞期间预防心肌缺血.
相关概念视频
Coronary Circulation
9.9K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
9.9K
Anastomoses
3.8K
In human anatomy, anastomosis refers to a connection or opening between two things, particularly between blood vessels or other tubular structures. The term is derived from the Greek term 'anastomosis,' which means 'outlet' or 'opening.' This natural network of connections plays a critical role in the survival and functionality of the human body.
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They...
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They...
3.8K
Autoregulation of Blood Flow
10.0K
Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....
10.0K


