状纳米容器分布到定义的细胞质有机体
Radoslav Savic1, Laibin Luo, Adi Eisenberg
1Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, H3G 1Y6, Canada.
概括
块共聚合物微粒可以将疏水药物传递给细胞器官,如线粒体,避免核. 这些纳米容器增强了药物递送,显示了针对药物递送的潜力.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 细胞生物学 细胞生物学
背景情况:
- 块共聚合物微粒是生物相容的纳米容器,用于疏水性药物输送.
- 了解细胞分布是有针对性的药物输送的关键.
- 亚细胞局部决定了治疗疗效.
研究的目的:
- 为了研究活细胞中阻断共聚合物微粒的亚细胞局部.
- 为了确定微粒是否可以选择性地针对特定的有机体.
- 评估菌体对输送剂的细胞吸收的影响.
主要方法:
- 使用了三重标记的共聚焦显微镜.
- 进行了活细胞成像.
- 分析了各种细胞区内的细胞局部.
主要成果:
- 在包括线粒体在内的多个细胞质器官中发现了菌丝.
- 在细胞核内没有观察到微粒.
- 菌株改变了细胞分布,并增加了输送剂的吸收.
结论:
- 区块共聚合物微粒表现出特定的亚细胞局部化模式.
- 这些细胞可以被导向细胞质有机细胞,不包括核.
- 菌体显示出增强针对性药物输送到亚细胞部位的前景.
相关概念视频
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For example, lysosomes in the animal cells...
For example, lysosomes in the animal cells...
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The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Eukaryotic Compartmentalization
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
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Differential Centrifugation
Differential centrifugation is...
Differential Centrifugation
Differential centrifugation is...
Distribution of Cytoplasmic Content
Cytokinesis segregates a cell’s chromosomes and organelles into its daughter cells. Organelles divide and grow prior to cell division but cannot be synthesized de novo; therefore, cells must receive at least one copy of each organelle to survive. Currently, many of the details of how the organelles are distributed are not yet fully elucidated.
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...
Distribution of cytoplasmic determinants
The cytoplasm contains various organelles, as well as salts, proteins, and water. The distribution of small...


