在628名患有原发性高胆固醇血症的患者中,以泽蒂米布与阿托瓦斯塔丁联合使用的效果:一项前性,随机,双盲试验
Christie M Ballantyne1, John Houri, Alberto Notarbartolo
1Baylor College of Medicine, 6565 Fannin Street, MS A-601, Houston, Tex 77030, USA. cmb@bcm.tmc.edu
Circulation
|April 30, 2003
概括
将ezetimibe添加到阿托瓦斯塔丁可以显著改善胆固醇水平,并且耐受性很好. 这种组合疗法为管理高胆固醇血症提供了有效的新选择,当单独使用他类药物不足时.
科学领域:
- 心血管医学 心血管医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 许多患者无法达到单独使用他类药物的目标LDL胆固醇 (LDL-C) 水平.
- 这些因素包括低于最佳剂量,高剂量他类药物的不良影响,以及对组合疗法的不耐受.
研究的目的:
- 评估在患有高胆固醇血症的患者中与阿托瓦斯塔丁同时使用ezetimibe的疗效和安全性.
主要方法:
- 一项双盲研究随机分配了628名患者,他们接受了12周的埃泽蒂米布,阿托瓦斯塔丁 (每天10-80毫克),埃泽蒂米布加阿托瓦斯塔丁或安慰剂.
- 主要终点:组合治疗与阿托瓦斯塔丁单一治疗的LDL-C的百分比降低.
主要成果:
- 与单独使用阿托瓦斯塔丁相比,埃泽蒂米布加阿托瓦斯塔丁显著改善了LDL-C,HDL-C,甘油三和hs-CRP (P<0.01).
- 同时使用导致额外的12%的LDL-C降低,3%的HDL-C增加,8%的甘油三降低和10%的hs-CRP降低.
- 结合治疗的LDL-C降低率在50%至60%之间.
结论:
- 埃泽蒂米布加上阿托瓦斯塔丁的安全性表现与单独的阿托瓦斯塔丁和安慰剂相似.
- 这种组合在降低脂质和hs-CRP方面提供了显著的增量效益.
- 埃泽蒂米布和阿托瓦斯塔丁的同时使用是一种耐受性良好,高效的高胆固醇血症治疗方法.
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