电子缺陷烯酸的高效环氧化,用一个阴离子复合体
Andrew Murphy1, Geraud Dubois, T D P Stack
1Department of Chemistry, Stanford University, Stanford, California 94305, USA.
Journal of the American Chemical Society
|May 2, 2003
概括
一种新型的复合物有效地利用最小的催化剂负载和短的反应时间来催化氧化. 这种实用的催化剂可以在广泛的烯基底物中实现高产量.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 绿色化学 绿色化学
背景情况:
- 奥莱芬环氧化是有机合成中的关键转化.
- 开发高效和实用的环氧化催化剂仍然是一个活跃的研究领域.
- 缺电子的烯对催化环氧化具有独特的挑战.
研究的目的:
- 开发和评估一种新型的复合物,作为缺乏电子的烯酸的环氧化催化剂.
- 为了证明开发的催化剂的效率,实用性和基质范围.
- 为了优化反应条件,以获得高产量和快速转化.
主要方法:
- 复合物的合成和表征 [MnII(R,R-mcp) ((CF3SO3) 2].
- 使用各种缺电子烯的催化环氧化反应.
- 优化催化剂负荷,反应时间和氧化剂固化学.
- 使用标准有机化学技术分析反应产品,以确定孤立产量.
主要成果:
- 复合物[MnII(R,R-mcp) ((CF3SO3) 2) 显示了烯酸氧化过程中具有很高的催化活性.
- 只有0.1mol%的催化剂负荷才能实现高效的环氧化.
- 用 peracetic 酸作为氧化剂,反应在不到 5 分钟内完成.
- 广泛的基质,包括终端,三级, cis/trans内部烯酸,烯酸和甲烯酸,被环氧化,分离产量>85%.
结论:
- [MnII ((R,R-mcp)) ((CF3SO3) 2)) 复合物是一种有效和实用的催化剂,用于缺电子的烯酸氧化.
- 催化剂表现出卓越的效率,广泛的基质范围和快速的反应速度.
- 这种催化系统为绿色和高效的环氧化物合成提供了宝贵的工具.
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