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通过调节跨膜螺旋体协会来激活整合素alphaIIbbeta3

Renhao Li1, Neal Mitra, Holly Gratkowski

  • 1Department of Biochemistry and Biophysics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Science (New York, N.Y.)
|May 6, 2003
PubMed
概括

整合素跨膜螺旋突变促进整合素αIIbbeta3的激活和聚类. 跨膜域的同质结合驱动整合素活性,为激活和聚类提供结构基础.

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