相关实验视频

Updated: Jul 14, 2026

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells
10:27

Spatio-Temporal Manipulation of Small GTPase Activity at Subcellular Level and on Timescale of Seconds in Living Cells

Published on: March 9, 2012

功能切换突变基因基于Ras超级家族小GTPases的形态分类

Won Do Heo1, Tobias Meyer

  • 1Department of Molecular Pharmacology, Stanford University School of Medicine, 269 Campus Drive, Room 3215, Stanford, CA 94305, USA.

Cell
|May 7, 2003
PubMed
概括

研究人员确定了信号蛋白中的关键氨基酸位置,以切换它们的细胞功能. 这一发现有助于理解蛋白质家族,并开发有针对性的疗法.

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Comparing the Affinity of GTPase-binding Proteins using Competition Assays

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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay13:51

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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