催化性纳米选择性施特克尔反应 基托胺的施特克尔反应
Shuji Masumoto1, Hiroyuki Usuda, Masato Suzuki
1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Journal of the American Chemical Society
|May 8, 2003
概括
研究人员使用性加多催化剂开发了一种新的催化酶选择性斯特雷克反应. 这种方法有效地从高选择性的多种基因胺中合成有价值的α-氨基酸前体.
科学领域:
- 有机化学 有机化学
- 催化剂是一种催化剂.
- 不对称的合成方法
背景情况:
- 斯特雷克反应是合成α-氨基酸的基本方法.
- 在制药和精细化学品中,开发酶选择性变体对于获得性构建块至关重要.
- N-diphenylphosphinoyl ketoimines 是合成转化的一种多功能基质类.
研究的目的:
- 开发一种新型的催化酶选择性施特克尔反应,用于N-二基胺.
- 为了利用一种性加多复合物作为这种转换的不对称催化剂.
- 为了证明开发的方法的广泛适用性和高抗选择性.
主要方法:
- 从Gd(OiPr) 3和d-葡萄糖衍生的配体中制备一种奇拉性加多复合催化剂.
- 催化对各种N-diphenylphosphinoyl ketoimines进行enantioselective的化.
- 使用奇拉色谱分析基质范围和酶选择性.
主要成果:
- 性加多复合物有效地催化了酶选择性斯特雷克反应.
- 对于广泛的基质,包括芳香,乙烯,初级基和α,β不和基因氨基胺,可以达到高的酶选择活性.
- 由此产生的化产品很容易转化为非替代的α-氨基酸和衍生物.
结论:
- 已经建立了一个新的,高效的,高分离选择性的催化方法,用于Strecker反应的N-diphenylphosphinoyl ketoimines.
- 开发的方法提供了一条有价值的途径,以获得奇拉性α-氨基酸前体.
- 性加多催化剂表现出广泛的基质普遍性和高立体控制.
相关概念视频
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