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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation
Published on: May 2, 2013
对于器官移植的耐受性免疫抑制
Thomas E Starzl1, Noriko Murase, Kareem Abu-Elmagd
1Thomas E Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. mangantl@msx.upmc.edu <mangantl@msx.upmc.edu>
Lancet (London, England)
|May 10, 2003
概括
这项研究表明,治疗前和移植后的最小免疫抑制策略,使用子抗胆小细胞球蛋白和塔克罗利,通过使耐受性诱导,显著改善器官移植生存率和生活质量.
科学领域:
- 移植免疫学 移植免疫学
- 免疫抑制策略 免疫抑制策略
背景情况:
- 器官移植和耐受机制为免疫抑制协议提供信息.
- 治疗原则包括接受者预治疗和移植后最小的免疫抑制.
- 适用于脏和外器官移植接受者.
研究的目的:
- 在器官移植中应用接受者预治疗和最小免疫抑制原则.
- 评估这种方法在不同器官接受者中的有效性和安全性.
主要方法:
- 82名患者在脏,肝脏,胰腺或肠道移植之前接受了子抗胆小细胞球蛋白预治疗.
- 移植后免疫抑制主要使用塔克罗利斯单一疗法.
- 如果耐受,则在4个月后间隔服用塔克罗利斯剂量.
主要成果:
- 一年后高患者存活率 (95%) 和移植存活率 (89%).
- 观察到与免疫抑制相关的最低发病率.
- 在72名存活移植的接受者中,有43人在13-18个月时接受了间隔的塔克罗利斯单疗法.
结论:
- 该策略促进了耐受性诱导,允许显著的免疫抑制.
- 这些原则在不同器官和免疫抑制药物中广泛适用.
- 系统应用可以提高长期移植存活率和患者的生活质量.
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