在孕妇中,内皮功能障碍和不对称二甲基氨基的血度升高,后者随后发展为子宫前症
Makrina D Savvidou1, Aroon D Hingorani, Dimitrios Tsikas
1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Lancet (London, England)
|May 10, 2003
概括
内皮功能障碍和不对称二甲基氨基 (ADMA) 水平升高,先于产前的发展. 这些标志物表明胎盘输液受损,并且与风险妊娠中的内皮功能障碍有关.
科学领域:
- 产科和妇科 产科和妇科
- 心血管研究研究心血管研究
- 围产儿医学 围产儿医学
背景情况:
- 在妊娠前中观察到母亲内皮功能障碍,但其作为原因或后果的作用尚不清楚.
- 非对称二甲基氨基 (ADMA) 是内皮氧化合成酶的内源性抑制剂.
- 这项研究调查了内皮功能障碍和ADMA升高是否先于妊娠前的发展.
研究的目的:
- 为了测试内皮功能障碍和血ADMA度升高的假设,先于并导致子宫前.
- 评估子宫动脉多普勒,内皮功能,ADMA水平和怀孕结果之间的关系.
主要方法:
- 在怀孕23-25周的86名妇女中评估了子宫动脉多普勒波形.
- 使用臂动脉的流媒体扩张来评估内皮功能.
- 在所有参与者身上测量出血ADMA度.
主要成果:
- 与正常结果的女性相比,患有先兆子的女性的流量介导扩张明显较低 (3.58%vs8.59%).
- 缺陷的胎盘 perfusion 与显著更高的ADMA水平 (2.4μmol/L 与 0.81μmol/L 相比) 有关.
- 在患有先兆子的女性中观察到ADMA和流媒体扩张之间的强烈反相关性 (r=-0.8,p=0.005).
结论:
- 在临床表现为子宫前之前,母亲的内皮功能受损.
- 在患有高抗性胎盘循环的妇女中,ADMA度升高可能会导致子前期.
- 在一些患有子宫前和子宫内生长限制 (IUGR) 风险的妇女中,ADMA与内皮功能障碍有关.
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