在常规接种和补充疫苗接种后,对B型Haemophilus influenzae的抗体
C L Trotter1, J McVernon, N J Andrews
1Immunisation Division, Communicable Disease Surveillance Centre, Health Protection Agency, 61 Colindale Avenue, NW9 5EQ, London, UK. caroline.trotter@hpa.org.uk <caroline.trotter@hpa.org.uk>
Lancet (London, England)
|May 10, 2003
概括
在英国,海莫菲勒斯流感b型 (Hib) 病例增加. 疫苗接种提高了儿童的抗体水平,这表明第二次追赶运动可以有效地减少疾病传播.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 自1999年以来,英国血流感b型 (Hib) 疾病的发病率在英国上升.
- 人口免疫水平对于理解和控制传染病动态至关重要.
研究的目的:
- 调查人口免疫在Hib病例增加中的作用.
- 评估Hib结合疫苗接种计划对儿童抗体标位的影响.
主要方法:
- 分析了来自英国1至15岁儿童的2600多个血清样本.
- 测量抗体标位以评估接种疫苗后的免疫反应.
主要成果:
- 在引入常规Hib合疫苗接种后,1岁儿童的中位抗体标位显著增加.
- 在最初的追赶活动中,在1-4岁时接种了第一剂疫苗的儿童,最初的抗体度比婴儿时接种疫苗的儿童高.
- 预计,针对6个月至4岁儿童的第二次追赶活动将非常有效.
结论:
- 常规的婴儿疫苗接种和追赶活动显著提高了人们对Hib的免疫力.
- 一个有针对性的第二次追赶活动可以快速提高免疫力,并减少短期Hib病发病率.
相关概念视频
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01:22Development of Immunocompetence
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The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:31Defense Against Bacterial Pathogens
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01:29Immune Response Against Viral Pathogens
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