Dan Cao1, Roy Parker

  • 1Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721, USA.

Cell
|May 22, 2003
PubMed
概括

无意中介衰变 (NMD) 降解了酵母中的有缺陷的mRNA. 这项研究揭示了NMD触发加速死乙烯和死乙烯独立脱落,其中5'无意义编码子显示了更快的脱落率.

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The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
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