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Updated: Jun 30, 2026

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
10:50

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Published on: September 16, 2010

在HIV-1蛋白酶中的有序水分子的热力学贡献

Zheng Li1, Themis Lazaridis

  • 1Department of Chemistry, City College of CUNY, Convent Avenue and 138th Street, New York, NY 10031, USA.

Journal of the American Chemical Society
|May 29, 2003
PubMed
概括

有序的水分子可以调解生物分子相互作用. 这项研究量化了HIV-1蛋白酶中特定结合的水分子的热力学影响,揭示了其对结合亲和力和热容量的重大贡献,有助于药物设计.

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