在治疗更年期热时控制释放的帕洛:一个随机对照试验
Vered Stearns1, Katherine L Beebe, Malini Iyengar
1Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, USA. vstearn1@jhmi.edu
JAMA
|June 5, 2003
概括
帕洛西丁可控释放 (CR) 有效地减少了更年期妇女的热症状. 这种选择性血清素再吸收抑制剂为治疗血管运动症状提供了传统激素替代疗法的有希望的替代方案.
科学领域:
- 生殖医学 生殖医学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 标准的热治疗包括激素替代疗法 (HRT).
- 新出现的证据表明抗抑郁药,特别是血清素再吸收抑制剂 (SRIs),也可能是有效的.
- 选择性血清素再吸收抑制剂 (SSRI) 正在作为治疗更年期血管运动症状的替代方案进行研究.
研究的目的:
- 为了评估帕罗素控制释放 (CR) 在缓解热的疗效.
- 评估帕洛克塞丁CR作为一种治疗绝经期妇女多样化人口的血管运动症状.
主要方法:
- 一项随机,双盲,安慰剂控制,并行组研究在美国17个地点进行.
- 参与了165名绝经妇女,每天至少有2-3次发热,并已停止HRT.
- 参与者接受了安慰剂,12.5毫克/天或25.0毫克/天的帕罗克塞丁CR在1周的安慰剂运行后6周.
主要成果:
- 与安慰剂相比,帕洛西丁CR显著降低了热的频率和严重程度.
- 热复合得分的中位数减少为12.5 mg/d组的62.2%和25.0 mg/d帕洛素CR组的64.6%,与安慰剂组的37.8%相比.
- 与安慰剂调整后的降低对于帕洛素CR剂量都具有统计学意义.
结论:
- 帕洛西丁CR在治疗更年期热方面表现出有效性.
- 这种选择性血清素再吸收抑制剂为激素替代疗法提供了可行的替代方案.
- 帕洛西丁CR是治疗更年期血管运动症状的良好的选择.
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