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Updated: Jul 8, 2026

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
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Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast

Published on: June 23, 2018

3-基林残留物对原蛋白稳定性的影响

Cara L Jenkins1, Lynn E Bretscher, Ilia A Guzei

  • 1Contribution from the Department of Chemistry and Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
概括

这项研究显示,3-基-l-proline (3-Hyp) 可以破坏原三重螺旋的稳定,与4-基-l-proline (4-Hyp) 不同. 它在原序列中的位置显著影响了这种对蛋白质稳定性的破坏效应.

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA Stability01:53

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Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Cis-acting Elements involved in mRNA stability
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The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
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