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用非核酸抑制剂TMC125对HIV-1逆转录酶复合物的模型的验证

Marina Udier-Blagović1, Julian Tirado-Rives, William L Jorgensen

  • 1Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
概括

确定并通过计算验证了与HIV-1逆转录酶结合的TMC125的结构. 这证实了该药物对野生型和突变HIV的有效性,有助于开发新的非核酸逆转录酶抑制剂 (NNRTIs).

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