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相关概念视频

Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis. This...
Magnetic Field Lines01:19

Magnetic Field Lines

The representation of magnetic fields by magnetic field lines is very useful in visualizing the strength and direction of the magnetic field. Each of the magnetic field lines forms a closed loop. The field lines emerge from the north pole (N), loop around to the south pole (S), and continue through the bar magnet back to the north pole.
Magnetic field lines follow several hard-and-fast rules:
Divergence and Curl of Magnetic Field01:26

Divergence and Curl of Magnetic Field

The magnetic field due to a volume current distribution given by the Biot–Savart Law can be expressed as follows:
Atomic Nuclei: Types of Nuclear Relaxation01:28

Atomic Nuclei: Types of Nuclear Relaxation

Nuclear relaxation restores the equilibrium population imbalance and can occur via spin–lattice or spin–spin mechanisms, which are first-order exponential decay processes.
In spin–lattice or longitudinal relaxation, the excited spins exchange energy with the surrounding lattice as they return to the lower energy level. Among several mechanisms that contribute to spin–lattice relaxation, magnetic dipolar interactions are significant. Here, the excited nucleus transfers energy to a nearby...
Bewley Lattice Diagram01:12

Bewley Lattice Diagram

The Bewley lattice diagram, developed by L. V. Bewley, effectively organizes the reflections occurring during transmission-line transients. It visually represents how voltage waves propagate and reflect within a transmission line, making it easier to understand the complex interactions that occur.

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相关实验视频

Updated: Jul 8, 2026

Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

Direct Imaging of Laser-driven Ultrafast Molecular Rotation

Published on: February 4, 2017

动态核磁共振线形分析表明,维林头饰子域在微秒时间尺度上折叠.

Minghui Wang1, Yuefeng Tang, Satoshi Sato

  • 1Department of Chemistry, State University of New York at Stony Brook, 11794-3400, USA.

Journal of the American Chemical Society
|June 6, 2003
PubMed
概括
此摘要是机器生成的。

研究人员使用动态核磁共振 (NMR) 发现,小小头部蛋白质在微秒时间尺度上快速折叠. 这种快速的蛋白质折叠发生在56度至78度C之间,速度约为10^5s^-1.

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High-Speed Magnetic Tweezers for Nanomechanical Measurements on Force-Sensitive Elements

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Last Updated: Jul 8, 2026

Direct Imaging of Laser-driven Ultrafast Molecular Rotation
10:52

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Published on: February 4, 2017

Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement
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Optimized Setup and Protocol for Magnetic Domain Imaging with In Situ Hysteresis Measurement

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科学领域:

  • 生物物理学的生物物理.
  • 结构生物学 结构生物学
  • 蛋白质动力学 蛋白质动力学

背景情况:

  • 具有快速折叠动态的小蛋白具有显著的兴趣.
  • 维林头饰子域是研究快速蛋白质折叠的模型系统.
  • 以前的理论和计算研究预测了这个子域的快速折叠.

研究的目的:

  • 实验性地确定维林头饰子域的折叠时间尺度.
  • 在生理温度下量化这个小蛋白质的折叠率.
  • 为了研究蛋白质折叠速率的温度依赖.

主要方法:

  • 使用动态核磁共振 (NMR) 线形分析.
  • 分析了三种不同的残留物的蛋白质共振.
  • 实验是在56-78°C的温度范围内的500和700 MHz场强度进行的.

主要成果:

  • 维林头饰子域被证明在微秒 (10微秒) 时间尺度上折叠.
  • 折叠率直接估计在0.5到2.0x10^5s^-1之间.
  • 折叠率在研究范围内的温度上表现出微弱的依赖.

结论:

  • 动态NMR线形分析提供了快速蛋白质折叠的准确测量.
  • 维林头饰子域迅速折叠,符合理论预测.
  • 这种小蛋白质的折叠动力学在适度温度范围内强大.