在子宫中糖尿病环境对2型糖尿病的倾向的影响
Eugène Sobngwi1, Philippe Boudou, Franck Mauvais-Jarvis
1Department of Endocrinology and Diabetes, Saint-Louis Hospital, Assistance Publique, Hôpitaux de Paris, University of Paris VII-Medical School;, Paris, France
Lancet (London, England)
|June 6, 2003
概括
在怀孕期间产妇糖尿病增加后代.
科学领域:
- 内分泌学和新陈代谢学
- 生殖生物学 生殖生物学
- 人类遗传学 人类遗传学
背景情况:
- 2型糖尿病 (T2DM) 的发展受到遗传和环境因素的影响.
- 在子宫内糖尿病环境对T2DM倾向的影响,独立于遗传背景,需要阐明.
研究的目的:
- 研究糖尿病环境中的子宫内暴露对成年后代葡萄糖代谢和胰腺功能的长期影响.
- 为了区分母亲和父亲糖尿病对后代代谢健康的影响,控制遗传倾向.
主要方法:
- 通过口服葡萄糖耐受性测试 (OGTT) 和静脉葡萄糖耐受性测试 (IVGTT) 评估胰岛素敏感性和胰岛素分泌.
- 研究包括1型糖尿病母亲的非糖尿病成年后代 (n=15) 和1型糖尿病父亲的后代 (n=16) 作为对照.
- 测量胰腺多水平,以评估副交感神经系统的活动.
主要成果:
- 两组之间没有观察到身体脂肪百分比或胰岛素敏感性的显著差异.
- 在5名暴露参与者中诊断出葡萄糖耐受性损害 (IGT),但没有一个对照组 (p=0.02).
- 暴露后代在OGTT期间表现出较低的早期胰岛素分泌率 (p=0.04) 和IVGTT期间较低的平均胰岛素分泌率 (p<0.0001).
- 胰腺多对口服葡萄糖的反应在暴露的个体中减少,特别是那些有IGT (p=0.04) 的个体.
结论:
- 在子宫内暴露在糖尿病环境中与在成年时较高的葡萄糖耐受性损失和缺陷胰岛素分泌率有关.
- 这些代谢变化独立于对2型糖尿病的遗传倾向而发生.
- 观察到的胰岛素分泌缺陷可能与降低的副交感音调有关,这需要进一步的流行病学研究和潜在的治疗策略开发.
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