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Updated: May 11, 2026

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells
13:20

Chromatin Immunoprecipitation (ChIP) to Assay Dynamic Histone Modification in Activated Gene Expression in Human Cells

Published on: July 30, 2010

基因基因因子诱导的基因表达过程中,IKK-alpha对基因基因因 H3 的酸化至关重要

Yumi Yamamoto1, Udit N Verma, Shashi Prajapati

  • 1Division of Hematology-Oncology, Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8594, USA.

Nature
|June 6, 2003
PubMed
概括

核IKK-alpha通过修改基因素功能来调节NF-kappaB依赖的基因表达. 这项研究揭示了IKK-alpha在细胞因子刺激后激活转录中的新型核作用.

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A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α11:27

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α

Published on: November 2, 2018

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Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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The heterodimer of NF-κB...
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