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氧化诱导的抗性动脉敏感度的降低是由于肌轻链酸酶的激活,并受到RhoA/Rho kinase通路的对抗

Steffen-Sebastian Bolz1, Lukas Vogel, Daniel Sollinger

  • 1Physiologisches Institut der Ludwig Maximilians Universität, Schillerstrasse 44, 80336 München, Germany. bolz@lrz.uni-muenchen.de

Circulation
|June 11, 2003
PubMed
概括

氧化 (NO) 通过激活髓轻链酸酶 (MLCP) 扩大阻力动脉,降低细胞敏感性. 该RhoA通路抵消这种效果,但Rho激酶抑制剂可以恢复NO介导的血管扩张.

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