个人暴露于二氧化 (NO2) 和儿童病毒引起的喘的严重程度
A J Chauhan1, Hazel M Inskip, Catherine H Linaker
1Respiratory, Cell, and Molecular Biology Research Division, University of Southampton, Southampton, UK. anoop.chauhan@porthosp.nhs.uk <anoop.chauhan@porthosp.nhs.uk>
Lancet (London, England)
|June 13, 2003
概括
在病毒感染前高氧化物 (NO2) 暴露会使儿童的喘恶化. 即使在空气质量标准内的水平也会增加症状严重程度并降低肺功能.
科学领域:
- 环境健康 环境健康
- 儿科呼吸系统医学 儿科呼吸系统医学
- 空气污染的毒理学
背景情况:
- 二氧化 (NO2) 是一种常见的空气污染物,与呼吸系统问题有关.
- 病毒感染是儿童喘恶化的主要触发因素.
- 二氧化暴露对病毒引起的喘严重性的特定影响需要进一步调查.
研究的目的:
- 确定二氧化 (NO2) 暴露与儿童喘恶化严重程度之间的关系.
- 评估NO2暴露是否会在经过证明的呼吸道病毒感染期间影响喘严重程度.
主要方法:
- 一组114名患有喘的儿童 (8-11岁) 每天监测症状,峰值呼气流 (PEF) 和个人每周暴露NO2,持续13个月.
- 在上呼吸道疾病发作期间收集了鼻吸液,并使用RT-PCR测试了常见病毒.
- 概括估计方程分析了NO2暴露三位数 (低,中,高) 与感染后喘恶化严重程度之间的关联.
主要成果:
- 在78%的感染发作中检测到病毒;NO2中位数为5,10和21μg/m3的低,中,高三角动物.
- 在NO2三位体中观察到下呼吸道症状得分的显著增加 (所有病毒p=0.05,RSVp=0.01).
- 与低暴露相比,高NO2暴露与皮科纳病毒引起的恶化 (p=0.04) 的PEF减少>12 L/min有关.
结论:
- 在病毒感染之前,即使在当前空气质量标准范围内,高氧化 (NO2) 暴露与儿童喘恶化严重程度的增加有关.
- 这表明NO2作为呼吸道病毒感染的增强剂,导致更严重的喘结果.
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