适应性进化驱动了两种多索菲拉菌种之间的杂交无活性基因的分歧
Daven C Presgraves1, Lakshmi Balagopalan, Susan M Abmayr
1Department of Biology, University of Rochester, Rochester, New York 14627, USA. dvnp@mail.rochester.edu
Nature
|June 13, 2003
概括
在物种进化中的繁殖隔离会导致杂交不活力. 一个核孔蛋白基因通过积极选择进化,导致致命的杂交不兼容性作为适应的副产品.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 规格研究研究 规格研究
背景情况:
- 品种化涉及生殖隔离,导致杂交不孕或不活力.
- 杂交不兼容性往往是由遗传位置之间的不兼容相互作用引起的.
- 这些不相容性的特定基因和进化驱动因素在很大程度上是未知的.
研究的目的:
- 为了确定对致命的杂交不兼容性负责的基因.
- 为了研究推动这些基因分歧的进化力量.
主要方法:
- 人口遗传分析 人口遗传分析
- 进行比较的基因组学.
- 候选基因的功能分析.
主要成果:
- 鉴定了一种编码核孔蛋白的特定基因,该基因导致Drosophila melanogaster和D. simulans杂交物体的表观无活性.
- 人口遗传分析表明,这种基因在两种物种的积极自然选择下演变.
- 证明了一种致命的混合不相容性是由适应性蛋白质进化的结果.
结论:
- 适应性蛋白质进化可以产生致命的混合不相容性.
- 核孔蛋白与物种化过程有关.
- 对相互作用基因的积极选择可以驱动生殖隔离.
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