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In Vitro Analysis of PDZ-dependent CFTR Macromolecular Signaling Complexes
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在上皮细胞中通过谷氨酸和ATP控制动态CFTR选择性

M M Reddy1, P M Quinton

  • 1Department of Pediatrics, UCSD School of Medicine, University of California, San Diego, La Jolla, California 92093-0831, USA. mmr@ucsd.edu

Nature
|June 13, 2003
PubMed
概括

细胞质谷氨酸激活了囊性纤维化跨膜导电调节器 (CFTR) 离子通道,独立于ATP和酸化. 这种谷氨酸激活的CFTR调节碳酸电导率,其损失有助于囊性纤维化严重程度.

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