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黑色素和棒形光感受系统在小鼠中占据了所有主要的辅助视觉功能
S Hattar1, R J Lucas, N Mrosovsky
1Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Nature
|June 17, 2003
概括
哺乳动物视网膜在视觉和昼夜调节方面使用了杆和黑斑系统. 这些系统协同工作,控制瞳孔反射和光引.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 时间生物学 时间生物学
背景情况:
- 哺乳动物的视网膜具有杆光受体和黑色素表达系统.
- 黑色素系统介导辅助视觉功能,如瞳孔光反射和昼夜光照引.
- 消去黑色素部分损害了这些功能,这表明其他光感受系统可能参与其中.
研究的目的:
- 为了研究棒和黑色素系统在哺乳动物辅助视觉功能中的作用.
- 为了确定额外的光感受系统是否有助于瞳孔光反射和昼夜节律调节.
主要方法:
- 对于生理节律阶段转移的动作频谱测量,在棒切除的小鼠中.
- 这种光谱与瞳孔光反射和黑色素光敏度的比较.
- 一代缺乏黑色素和棒光传导的小鼠.
主要成果:
- 在经过棒切除的小鼠中,昼夜节律相位转移的作用谱与瞳孔光反射谱和黑色素光敏度相匹配.
- 缺乏黑色素和功能性棒的小鼠显示出瞳孔反射的完全损伤,光/黑暗循环的吸收,以及光掩饰反应.
结论:
- 棒和黑色素光感受系统是必不可少的,它们共同负责辅助视觉功能的所有光输入.
- 这两种系统似乎是瞳孔光反射,昼夜光照引和对光的掩饰反应的唯一贡献者.
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