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在冠状动脉疾病患者中,定期体育活动通过增加内皮氧化合成酶的酸化来改善内皮功能
1Heart Center, Department of Cardiology, University of Leipzig, Germany. hamr@medizin.uni-leipzig.de
Circulation
|June 18, 2003
概括
运动训练可以改善稳定的冠状动脉疾病 (CAD) 患者的血管功能. 这种改善与内皮氧化合成酶 (eNOS) 活性增加有关,促进更好的血液流动.
科学领域:
- 心血管医学 心血管医学
- 运动生理学 运动生理学
- 分子生物学分子生物学
背景情况:
- 稳定的冠状动脉疾病 (CAD) 患者从运动训练中受益,这对动脉内皮功能有积极的影响.
- 来自内皮NO合成酶 (eNOS) 的氧化 (NO) 对于预防动脉样硬化至关重要.
- 这项研究研究了运动训练对内皮功能,eNOS表达和左内乳动脉 (LIMA) 中的Akt依赖eNOS酸化的影响.
研究的目的:
- 检查运动训练如何影响稳定CAD患者的内皮功能.
- 评估LIMA中运动训练,eNOS表达和Akt依赖的eNOS酸化之间的关系.
主要方法:
- 17名训练患者和18名对照患者接受了内皮依赖血管扩张和平均峰值流速 (APV) 的侵入性测量,以响应乙胆.
- 在LIMA组织中,使用西斑和RT-PCR分析了eNOS表达,-eNOS-Ser1177,Akt和-Akt.
- 测量是在基线和运动干预4周后进行的.
主要成果:
- 运动训练显著增加了LIMA血管扩张,对乙胆的反应增加了56%.
- 接受过培训的患者显示,eNOS蛋白表达增加了2倍,eNOS Ser1177-酸化增加了4倍.
- 在Akt酸化,-eNOS水平和APV变化之间发现了正相关性.
结论:
- 在稳定的CAD中,运动训练增强了主激素介导,内皮依赖的血管扩张.
- 观察到的血管扩张的改善与eNOS在Ser1177.7的剪切应力诱导的Akt依赖酸化密切相关.
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