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Updated: Jul 16, 2026

Synthesis of an Intein-mediated Artificial Protein Hydrogel
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蛋白质假肢:一种非自然残留物加速折叠,增加稳定性

Ulrich Arnold1, Matthew P Hinderaker, Jens Köditz

  • 1Department of Biochemistry/Biotechnology, Martin-Luther University, 06099 Halle, Germany.

Journal of the American Chemical Society
|June 19, 2003
PubMed
概括

用非天然的氨基酸替换ribonuclease A中的proline残留物加速蛋白质折叠六倍并改善稳定性. 这种蛋白质工程策略增强了治疗性蛋白质潜力,用于体内生存和口服.

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Protein Organization01:13

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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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