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Updated: May 2, 2026

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
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通过抑制DNA复制许可证,CUL-4泛素酶保持了基因组的稳定性

Weiwei Zhong1, Hui Feng, Fernando E Santiago

  • 1Department of Cellular Biology, University of Georgia, Athens, Georgia 30602, USA.

Nature
|June 20, 2003
PubMed
概括

CUL-4 泛基因酶通过降解 C. elegans 中的 CDT-1 蛋白质来防止 DNA 重复制. 无活化CUL-4导致大规模的DNA重复复制,突出其在细胞周期控制中的作用.

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