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Updated: Jul 17, 2026

In vivo and in vitro Studies of Adaptor-clathrin Interaction
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Published on: January 26, 2011

在单链DNA上进行渐进式AID催化细胞因子去胺,模拟体质突变

Phuong Pham1, Ronda Bransteitter, John Petruska

  • 1Department of Biological Sciences, Hedco Molecular Biology Laboratories, University of Southern California, University Park, Los Angeles, California 90089-1340, USA.

Nature
|June 24, 2003
PubMed
概括

激活诱导的cytidine除氨酶 (AID) 在单链DNA上将细胞素除氨化为 uracil,针对特定的WRC序列. 这种酶在个别的DNA链上进行多次除,解释了抗体基因突变的关键特征.

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