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新型指数用于对冠状动脉微循环进行侵入性评估

William F Fearon¹, Leora B Balsam, H M Omar Farouque

¹Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305, USA. wfearon@stanford.edu

|June 25, 2003

概括

通过使用冠状动脉压力线开发了一种新的微循环阻力 (IMR) 指数. 这种方法提供了简单的,对冠状动脉微循环的定量评估,与真正的微循环阻力相对应.

科学领域:

心血管研究研究心血管研究
干预心脏病学干预心脏病学
生理学生理学生理学

背景情况:

评估冠状动脉微循环独立于上心动脉需要一个简单的,侵入性的方法.
目前的方法可能缺乏定量准确性或简单性,无法广泛临床使用.

研究的目的:

开发和验证一种新的微循环电阻指数 (IMR).
评估IMR和真微循环阻力 (TMR) 之间的相关性.

主要方法:

使用冠状动脉压力线和修改软件来测量高血压平均传输时间.
计算的IMR是远距离冠状动脉压除以高血压平均传输时间的逆值.
在约克郡猪中比较IMR与TMR (距离LAD压力除以高血压流量).

主要成果:

在微循环中断后,IMR和TMR显著增加,无论有没有心表狭窄.
在IMR和TMR的变化是相似的和独立于心上动脉状态.
观察到IMR和TMR值及其相应的百分比变化之间存在显著的相关性.

结论:

测量IMR提供了一种简单,定量和侵入性的方法来评估冠状动脉微循环.
这种技术可以提高临床环境中微血管功能的评估.

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