所有的血压基因都在哪里?
1Department of Physiology, University of Melbourne, Victoria 3010, Australia. s.harrap@unimelb.edu.au
Lancet (London, England)
|June 27, 2003
概括
鉴定高血压的遗传原因仍然具有挑战性,因为有许多低影响性等位基因. 发现单个调节血压的等位基因可能会彻底改变高血压的治疗和预防策略.
科学领域:
- 基因组学就是基因组学.
- 心血管遗传学 心血管遗传学
背景情况:
- 人类基因组项目旨在发现高血压等常见疾病的遗传原因,从而实现个性化医学.
- 最近的大规模基因组研究为确定高血压的基因和DNA变异 (等位基因) 提供了有限的证据.
- 之前的研究对血压调节基因的位置缺乏共识.
研究的目的:
- 为了解决确定高血压的遗传决定因素的挑战.
- 探索发现特定与血压相关的等位基因的潜在影响.
主要方法:
- 关于高血压最近的大规模基因组研究的综述.
- 分析识别常见复杂疾病遗传原因的困难.
主要成果:
- 发现了特定高血压决定基因和致病性DNA变异的有限证据.
- 遗传发现的挑战归因于众多的,小效应的,和特定于种群的等位基因.
- 目前对高血压的遗传诊断在没有全面的等位基因数据的情况下仍然不确定.
结论:
- 对于可靠的遗传诊断,需要对高血压相关的等位基因进行全面描述.
- 发现一个单一的血压控制等位基因可以确定新的生理目标.
- 这可能会大大促进高血压的预防和治疗.
相关概念视频
Genetic Lingo
Overview
Blood Pressure
Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
Factors affecting Blood pressure
Several physiological and lifestyle factors influence blood pressure (BP). Understanding these factors is crucial as they are significant in patient education and blood pressure management.
Physiological Factors:
Physiological Factors:
Alterations in Blood Pressure
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Hypertension and Regulation of Blood Pressure
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Blood Pressure
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...


