相关实验视频
Updated: May 11, 2026

07:29
Programmed Electrical Stimulation in Mice
Published on: May 27, 2010
在植入心脏转换器-除器的患者中,心脏起器刺激的前节律效应
Ewald Himmrich1, Oliver Przibille, Christian Zellerhoff
1II. Medical Clinic, University Hospital, Langenbeckstrasse 1, D-55131 Mainz, Germany. himmrich@2-med.klinik.uni-mainz.de
Circulation
|July 2, 2003
概括
心脏起器刺激可以触发患有植入式心脏转换器-除器的患者危险的腹腔动脉节律失常. 关闭起器或编程更长的逃逸间隔可以防止这些起器诱导的心跳动.
科学领域:
- 电力生理学 电力生理学
- 心脏病学 心脏病学
- 医疗器械 医疗器械
背景情况:
- 植入式心脏转换器-除器 (ICD) 用于治疗危及生命的腹腔动脉节律失常症.
- 心脏起器诱导的心跳动 (PIT) 是患有ICD和心脏起器的患者的潜在并发症.
研究的目的:
- 在ICD患者中调查右心室VVI备用节奏的前节律潜力.
- 为了确定心脏起器刺激是否可以诱导心室动脉节律失常症.
主要方法:
- 一项前性交叉研究,涉及仅患有心脏起器诱导的心跳动 (PIT) 的患者.
- 患者被随机分配到心脏起器关闭或被编程为每分钟60拍,随后进行交叉.
- 进行了1年的随访,以观察PIT的复发.
主要成果:
- 在150名患者中,39人 (26%) 经历了PIT,其中13人 (8.6%) 完全.
- 当心脏起器被关闭时,没有发生PIT.
- 将心脏起器编程为每分钟60次,导致6名患者中有5名患有PIT复发.
结论:
- 心脏起器刺激对ICD患者具有前节律效应,诱导PITs.
- PIT可以引起临床症状并触发抗心动治疗.
- 在患有PIT和没有心脏起器的患者中,应该关闭设备或以最长的脱离间隔编程设备.
相关概念视频
Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
Disturbances in Heart Rhythm
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
Dysrhythmias III: Characteristics of Dysrhythmias
Dysrhythmias, also known as arrhythmias, are irregular heart rhythms that result from abnormal electrical activity in the heart, affecting its ability to circulate blood efficiently. Tachyarrhythmias, a subset of dysrhythmias, are characterized by abnormally fast heart rates exceeding 100 beats per minute. Here are some types of tachyarrhythmias with their distinct ECG features:Sinus Tachycardia:Sinus tachycardia presents a regular heart rhythm with an increased rate of 101-180 beats per minute.
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Bradyarrhythmias are cardiac rhythm disorders characterized by a slower-than-normal heart rate, typically defined as fewer than 60 beats per minute. Some of which are discussed here:Sinus BradycardiaSinus bradycardia presents a heart rate lower than 60 beats per minute, with a regular rhythm originating from the SA node. The ECG typically shows normal P waves preceding each QRS complex, a normal PR interval (0.12 to 0.20 seconds), and a normal QRS duration (0.06 to 0.10 seconds).First-Degree AV...
Dysrhythmias VI: Management of Dysrhythmias
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Arrhythmia is a condition characterized by an irregular heart rhythm, with ECG changes that differ based on its origin and nature. The types of arrhythmias discussed below include atrial, junctional, and ventricular arrhythmias.Atrial ArrhythmiasPremature Atrial Complexes (PACs): PACs are early atrial beats caused by stress, caffeine, alcohol, electrolyte imbalances, hypoxia, hyperthyroidism, or certain medications (e.g., bronchodilators and decongestants). The ECG shows early P waves with an...

