血中C反应蛋白的度和计算的弗雷明汉冠状动脉心脏病风险评分
Michelle A Albert1, Robert J Glynn, Paul M Ridker
1Center for Cardiovascular Disease Prevention, Division Cardiovascular Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02115, USA. maalbert@partners.org
Circulation
|July 2, 2003
概括
在不使用激素替代疗法的个体中,C-反应蛋白 (CRP) 水平与弗雷明汉冠状动脉心脏病风险评分 (FCRS) 相对相关. 然而,CRP与单个FCRS组件的相关性很小,这表明它作为辅助心血管风险预测器的潜力.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 风险评估 风险评估
背景情况:
- C-反应蛋白 (CRP) 是已知的血管风险预测因素.
- 关于CRP与弗雷明翰冠状动脉心脏病风险评分 (FCRS) 之间的关系的数据有限.
研究的目的:
- 评估CRP水平与10年FCRS之间的关联.
- 为了确定CRP是否与FCRS的单个组件相关.
主要方法:
- 对1666个没有心血管疾病的人进行横截面调查.
- 将CRP水平与计算的10年FCRS进行比较.
- 通过激素替代疗法 (HRT) 使用进行分层分析.
主要成果:
- 在不使用HRT的男性和女性中,CRP水平与10年FCRS类别有显著的相关性 (p<0.01).
- CRP与个人FCRS组件的相关性很小,包括年龄,胆固醇,血压,糖尿病和吸烟状况.
- 在使用HRT的女性中没有发现显著的CRP-FCRS关系,尽管子组分析有限.
结论:
- 在非HRT的男性和女性中,CRP水平与整体10年FCRS有显著的相关性.
- 由于CRP与单个FCRS组件之间的相关性很小,因此需要进一步调查.
- CRP可以作为全球心血管风险预测的宝贵辅助.
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