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从未受保护的AB2构建块中快速合成聚胺树突
Masaki Okazaki1, Isao Washio, Yuji Shibasaki
1Department of Organic and Polymeric Materials, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
Journal of the American Chemical Society
|July 3, 2003
概括
一种新的,快速的方法可以在没有保护步骤的情况下高效地合成聚胺树突. 这种融合方法产生了使用新型凝结剂和特定的AB2构建块的第三代树突体.
科学领域:
- 聚合物化学 聚合物化学
- 有机合成 有机合成
- 材料科学 材料科学 材料科学
背景情况:
- 登德里默合成通常需要复杂的保护/解除保护步骤,增加时间和成本.
- 聚胺树脂体是一种多功能宏分子类,在各种领域都有潜在的应用.
- 有效和精简的合成路径对于更广泛的树枝状物利用至关重要.
研究的目的:
- 为聚胺树状体开发一种快速高效的合成方法.
- 在不需要保护/解除保护策略的情况下,实现第三代聚胺树突分子的合成.
- 为了证明二二二二三二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二二
主要方法:
- 对于树突分子制备,采用了融合合成策略.
- 使用凝结剂二烯酸 (2,3-二二-三-二醇) 酸盐 (DBOP) 激活了树突体的焦点.
- 激活的胺经过了与AB2构建块,3,5-bis(4-aminophenoxy) 酸的凝结.
主要成果:
- 成功合成了一种对称分支的第三代聚胺树枝体.
- 合成方法被证明是快速的,避免了繁的保护和解除保护的步骤.
- 使用DBOP在融合合成中促进了高效的胺键形成.
结论:
- 已经确定了聚胺树枝状体的简单快速合成途径.
- 这种方法提供了显著的优势,因为它消除了保护/解除保护的步骤,简化了树枝状物制备.
- 开发的策略是有效的,用于构建明确的,分支的聚胺树枝.
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