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Updated: Jul 6, 2026

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

一种oxazaphospholidine方法,用于立体控制的聚核酸酸酸的合成

Natsuhisa Oka1, Takeshi Wada, Kazuhiko Saigo

  • 1Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, Kashiwa, Chiba 277-8562, Japan.

Journal of the American Chemical Society
|July 3, 2003
PubMed
概括

这项研究详细介绍了一种新方法,用于使用oxazaphospholidine单体合成酸寡氧化核化物 (PS-ODN) 的立体控制合成. 这种方法实现了高立体选择性,允许生产纯 (R(p)) -和 (S(p)) -PS-ODN,用于固体相合成等应用.

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