在负面检查后3年重复的西格莫视镜检查结果
Robert E Schoen1, Paul F Pinsky, Joel L Weissfeld
1Department of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA. rschoen@pitt.edu
JAMA
|July 3, 2003
概括
在阴性检查检测到晚期腺瘤和远端结肠癌3年后,重复柔性晶体镜 (FSG) 查. 这些发现引发了人们对扩大结直肠癌预防查间隔的担忧.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 在阴性内镜检查后,对结直肠癌的最佳查间隔仍然不清楚.
- 了解重复查的产量对于制定有效的指南至关重要.
研究的目的:
- 在最初的负面查后三年,使用重复柔性晶体镜 (FSG) 评估远端结肠腺瘤和癌症的检测率.
- 在结直肠癌查中评估重复FSG发现的临床意义.
主要方法:
- 利用前列腺,肺,结肠直肠和卵巢 (PLCO) 癌症查试验的数据,这是一项随机对照研究.
- 包括接受了基线FSG和3年后重复FSG的参与者,其中9317人返回第二次查.
- 追踪诊断评估的结果,以检测屏幕检测出的异常.
主要成果:
- 总共有13.9% (1292/9317) 的参与者在重复FSG检测出了多或质块.
- 在3.1% (292/9317) 的个体中,在远端结肠中发现了腺瘤或癌症.
- 在0.8% (78/9317) 的病例中检测到晚期腺瘤 (72) 或癌症 (6),大多数晚期病变是在之前检查的区域中发现的.
结论:
- 在阴性检查后三年重复柔性晶体镜检查有效检测晚期腺瘤和远端结肠癌.
- 检测到显著的异常,即使在一个温和的速度,表明三年间隔可能对一些个人来说太长了.
- 这些发现凸显了在结直肠癌预防策略中重新考虑延长查间隔的必要性.
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