患有慢性疼痛和垂体功能异常的患者需要进行调查
Z Merza1, N Edwards, S J Walters
1Division of Clinical Sciences, Northern General Hospital, UK. r.j.ross@sheffield.ac.uk <r.j.ross@sheffield.ac.uk>
Lancet (London, England)
|July 5, 2003
概括
阿片类药物缓解疼痛不会导致垂体问题. 这项研究发现,口服阿片类止痛药在慢性疼痛患者中不会导致垂体功能异常,这表明内分泌异常的其他因素.
科学领域:
- 内分泌学 在内分泌学.
- 疼痛管理 疼痛管理
- 药理学 药理学是指药理学的学科.
背景情况:
- 滥用阿片类药物与垂体功能异常有关.
- 慢性疼痛患者经常报告疲劳,并接受内分泌检测.
- 治疗性口服阿片类药物使用对垂体功能的影响需要澄清.
研究的目的:
- 在接受口服阿片类止痛药的患者中前性评估垂体功能.
- 为了确定口服阿片类药物治疗是否与慢性疼痛中的异常垂体功能有关.
- 调查慢性疼痛患者内分泌异常的潜在原因.
主要方法:
- 预期评估下垂体功能.
- 研究包括37名患有慢性疼痛的患者.
- 患者接受口服阿片类止痛药和非阿片类止痛药之间的比较.
主要成果:
- 口服阿片类药物治疗与异常的垂体功能无关.
- 少数患者表现出异常的内分泌结果,主要与肥胖有关.
- 慢性疼痛患者的异常内分泌发现不太可能是由于阿片类药物止痛.
结论:
- 治疗性口服阿片类药物用于慢性疼痛似乎不会导致垂体功能障碍.
- 慢性疼痛患者经历异常的内分泌结果需要全面评估.
- 在这个人群中,肥胖是解释内分泌检测结果时需要考虑的重要因素.
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