母亲的DDT和DDE暴露以及女儿怀孕的时间
Barbara A Cohn1, Piera M Cirillo, Mary S Wolff
1Child Health and Development Studies, Center for Research on Women's and Children's Health, Public Health Institute, 1683 Shattuck Avenue, Suite B, Berkeley, CA 94709, USA. crwch@emf.net <crwch@emf.net>
产前暴露于bis[4-chlorophenyl]-1,1,1-trichloroethane (p,p'-DDT) 与女儿怀孕率的降低有关. 然而,暴露于其代谢物 bis[4-chlorohenyl]-1,1-dichloroethene (p,p'-DDE) 的情况显示与怀孕概率有积极的关联.
科学领域:
- 环境科学 环境科学
- 生殖毒理学 生殖毒理学
- 流行病学 流行病学
背景情况:
- 在子宫内暴露于乙醇 (DES) 导致生殖异常,引发了对环境污染物的担忧.
- 双[4-烯]-1,1,1-三乙烯 (p,p'-DDT) 和其代谢物双[4-烯]-1,1-二乙烯 (p,p'-DDE) 是持久性环境污染物,具有较弱的雌激素特性.
研究的目的:
- 调查p,p'-DDT和p,p'-DDE产前暴露与后来的女儿生育能力之间的关联.
- 探索观察到的生殖效应背后的潜在机制.
主要方法:
- 1960-1963年的母体血清样本被分析为p,p'-DDT和p,p'-DDE度.
- 怀孕的时间记录了289名28-31岁的长女.
- 进行了统计分析,以评估污染物水平与怀孕概率之间的关系.
主要成果:
- 每增加10微克/升的母体血清p,p'-DDT,女儿怀孕概率下降32%.
- 每增加10微克/升的母亲血清p,p'-DDE,女儿怀孕概率增加16%.
- 与p,p'-DDT相关的降低生育能力的机制尚不清楚.
结论:
- 产前暴露于p,p'-DDT可能会对女性生育能力产生负面影响.
- 对于p,p'-DDE的抗雄激素活性,可能会对对卵巢的不良雄激素影响产生保护作用.
- 需要进一步的研究来阐明有机农药对生殖的复杂影响.
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