在EuroSIDA研究中艾滋病和死亡率的下降:一项观察性研究
A Mocroft1, B Ledergerber, C Katlama
1Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK. a.mocroft@pcps.ucl.ac.uk
Lancet (London, England)
|July 11, 2003
概括
高活性抗逆转录病毒疗法 (HAART) 的持续有效性在欧洲显著降低了HIV-1死亡率和艾滋病发病率. 这些积极的结果证明了HAART.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 高活性抗逆转录病毒疗法 (HAART) 对HIV-1死亡率和发病率的长期影响仍在调查中.
- 评估这些比率的持续变化对于了解HAART持续有效性至关重要.
研究的目的:
- 评估在HAART引入后欧洲HIV-1死亡率和发病率的持续变化.
- 分析不同治疗时代对患者治疗结果的影响.
主要方法:
- 分析了包括以色列和阿根廷在内的70个欧洲艾滋病毒中心的9803名患者的数据.
- 基于CD4计数和治疗时代的艾滋病或死亡发病率的计算 (前HAART,早期HAART,晚期HAART).
- 利用多变量考克斯模型来评估与不同治疗期相关的风险.
主要成果:
- 1998年9月以后,艾滋病或死亡发生率显著下降 (每6个月8%).
- 所有死亡的发生率在晚期的HAART时代显著低于早期的HAART时代,对于CD4计数≤20细胞/μL的患者来说.
- 艾滋病发病率在晚期的HAART时代比早期的HAART时代低约50%,无论CD4计数如何.
结论:
- 在HAART引入后,死亡率和发病率的最初降低一直持续.
- 对HAART的潜在长期不良影响并没有降低其在治疗艾滋病方面的有效性.
相关概念视频
Deindividuation
Deindividuation is a form of social influence on an individual’s behavior such that the individual engages in unusual or non-normal behavior while in a group setting. Why? Because in these group settings, the individual no longer sees themselves as an individual anymore, disinhibiting their behavior and personal restraint.
Overview of Cell Death
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the 20th century...
EPS and iPS Cells in Disease Research
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
Bias in Epidemiological Studies
Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
Statistical Methods for Analyzing Epidemiological Data
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
Censoring Survival Data
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different reasons...


