谷氨酸受体介导的编码和获取配对关联的学习
M Day1, R Langston, R G M Morris
1Laboratory for Cognitive Neuroscience, Division and Centre for Neuroscience, The University of Edinburgh, 1 George Square, Edinburgh EH8 9JZ, UK.
Nature
|July 11, 2003
概括
老鼠学习独特的食物位置对,使用海马进行记忆编码和回忆. 重复学习的对在其他地方得到巩固,独立于海马活动.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 动物行为 动物行为
背景情况:
- 情节性记忆对于回忆特定事件至关重要.
- 动物模型对于理解记忆机制至关重要.
- 配对关联学习模型人类情节性记忆.
研究的目的:
- 开发一种用于研究情节性记忆的老鼠模型.
- 研究海马在编码和回忆独特的空间嗅觉关联中的作用.
- 区分海马在编码新与重复学习的关联中的角色.
主要方法:
- 老鼠学会了独特的味道位置对.
- 河马N-甲基-d-酸盐 (NMDA) 和α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) 受体被阻断. 这些受体被阻断.
- 记忆回忆被测试使用提示检索.
- 第二项研究涉及对联员工的重复训练.
主要成果:
- 阻塞NMDA受体损害了记忆编码,但没有回忆.
- 在海马体中AMPA受体的阻塞损害了独特对的编码和回忆.
- 经过多次训练的配对合作伙伴即使在AMPA受体阻塞的情况下也被召回.
- 这表明,新记忆与巩固记忆之间有不同的海马体作用.
结论:
- 独特的"什么-何处"配对协会依赖于海马的编码和检索.
- 重复学习的关联的巩固发生在海马外电路中.
- 海马对于新的关联性记忆形成和检索至关重要.
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