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Updated: Apr 30, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses
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通过Vif从HIV-1病毒中排除APOBEC3G的物种特异性排除

Roberto Mariani1, Darlene Chen, Bärbel Schröfelbauer

  • 1Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.

Cell
|July 16, 2003
PubMed
概括

艾滋病毒-1 Vif 蛋白质防止 APOBEC3G 被包装成新的病毒,阻止病毒复制. 这种相互作用是物种特异性的,可能会将HIV-1限制在人类宿主身上.

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
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